2022 Acura MDX vs 2021 Lexus GX Comparison

2022 Acura MDX vs. 2021 Lexus GX

$46,900 MSRP*

Starting Price

$53,250 MSRP

Available Trim Levels

71.4 cubic feet

Cargo Capacity

64.7 cubic feet
3.5L V6 engine


4.6L V8 engine
19 mpg city / 26 mpg hwy**

EPA-Estimated MPG

15 mpg city / 19 mpg hwy
10-speed automatic transmission


6-speed automatic transmission

Drivers looking to upgrade their Costa Mesa commute with a powerful and spacious luxury crossover may be stuck between options like the 2022 Acura MDX or 2021 Lexus GX 460. Each model offers its own pricing, performance, and features, but only one can end up in your driveway. Find the right luxury crossover to keep you moving by comparing the Acura MDX vs. Lexus GX 460 with Weir Canyon Acura today!

Acura MDX vs. Lexus GX 460: Pricing and Configurations

Shopping for a luxury crossover doesn’t mean you have to break the bank on your next purchase. That’s why you’ll appreciate the more competitive price of the Acura MDX FWD, which has a $46,900 MSRP* compared to the $53,250 MSRP of the Lexus GX 460. If you also love having more choices when shopping for your next vehicle, the MDX offers four packages to choose from, compared to the only three configurations available on the GX lineup.

Acura MDX vs. Lexus GX 460: Interior Dimensions

Whether you’re running errands around Tustin or packing up for your next trip on the open road, you want plenty of space in your next luxury crossover. You can choose between six-or seven-passenger configurations in either lineup, however, when you fold down the second row and rear seats of the MDX, you’ll have more cargo space to fit large quantities or bulky items. Compare the different cargo dimensions for the MDX and GX 460 below:

2022 Acura MDX:

  • 71.4 cubic feet of cargo space behind the first row
  • 39.1 cubic feet of cargo space behind the second row
  • 16.3 cubic feet of cargo space behind the third row

2021 Lexus GX:

  • 64.7 cubic feet of cargo space behind the first row
  • 46.7 cubic feet of cargo space behind the second row
  • 11.6 cubic feet of cargo space behind the third row

Acura MDX vs. Lexus GX 460: Performance

You also expect a luxury crossover to transform your Montclair commute with an enhanced performance. While you may be intrigued by the slightly larger engine of the Lexus GX, the Acura MDX offers a stronger transmission and standard drivetrain over its competitor. When you opt for the MDX, you can also equip your luxury ride with the available Super-Handling All-Wheel Drive system for even more precision control and handling. Take a look at how the specs for the Acura MDX vs. Lexus GX 450 compare below:

2022 Acura MDX FWD:

  • 3.5L V6 engine
  • 10-speed automatic transmission
  • 19 mpg city / 26 mpg hwy** rating

2021 Lexus GX 460 4WD:

  • 4.6L V8 engine
  • 6-speed automatic transmission
  • 15 mpg city / 19 mpg hwy rating

Lease or Finance a New Acura MDX for Sale at Weir Canyon Acura

After comparing the new Acura MDX vs. Lexus GX 460, experience the difference on Costa Mesa roads behind the wheel of your very own Acura crossover. Find a new Acura MDX for sale from Weir Canyon Acura, and browse our online selection of new vehicle specials and national offers for more exciting Acura packages. Apply for financing or value your trade-in online, or speak with our sales team who can answer your questions. Contact us today for more details on the Acura MDX vs. Lexus GX 460, and stop by our Anaheim dealership for a test drive!

*Prices shown are Acura suggested retail prices only and do not include taxes, license or destination and handling charge. Destination & Handling charge for sedans (excluding PMC Edition) and SUVs (excluding PMC Edition) is $1,025.00. Destination & Handling charge for PMC Edition models and NSX is $1,995.00. Acura vehicle accessory costs, labor and installation vary. Dealers set their own prices. Please consult your selected dealer.

**Based on 2022 EPA mileage ratings. Use for comparison purposes only. Your actual mileage will vary, depending on how you drive and maintain your vehicle, driving conditions, battery pack age/condition (hybrid only) and other factors.

Weir Canyon Acura 33.8769357, -117.75044.